Mark Petersen, MD

Associate Professor
Pediatrics
[email protected]
+1 415 476-3728

Dr. Mark Petersen is a neonatologist and neuroscientist who serves as director of the UCSF Neuro-Intensive Care Nursery. He cares for premature and critically ill infants and leads research focused on pioneering treatments for newborn brain injury. Dr. Petersen and his wife, Allison, have been married for over 20 years and are proud parents to four children. Together, they enthusiastically cheer on their kids at countless games and meets, reliving their own “glory days” from the sidelines.

Publications: 

Pioneering discovery and therapeutics at the brain-vascular-immune interface.

Cell

Akassoglou K, Davalos D, Mendiola AS, Petersen MA, Ryu JK, Schachtrup C, Yan Z

Fibrin drives thromboinflammation and neuropathology in COVID-19.

Nature

Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption.

Proceedings of the National Academy of Sciences of the United States of America

Weaver O, Gano D, Zhou Y, Kim H, Tognatta R, Yan Z, Ryu JK, Brandt C, Basu T, Grana M, Cabriga B, Alzamora MDPS, Barkovich AJ, Akassoglou K, Petersen MA

Assessing for prenatal risk factors associated with infant neurologic morbidity using a multivariate analysis.

Journal of perinatology : official journal of the California Perinatal Association

Jain S, Oltman S, Rogers E, Ryckman K, Petersen M, Baer RJ, Rand L, Piao X, Jelliffe-Pawlowski L

BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis.

Brain : a journal of neurology

Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K

Correction: Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California.

Journal of perinatology : official journal of the California Perinatal Association

Karvonen KL, Baer RJ, Rogers EE, Steurer MA, Ryckman KK, Feuer SK, Anderson JG, Franck LS, Gano D, Petersen MA, Oltman SP, Chambers BD, Neuhaus J, Rand L, Jelliffe-Pawlowski LL, Pantell MS

Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California.

Journal of perinatology : official journal of the California Perinatal Association

Karvonen KL, Baer RJ, Rogers EE, Steurer MA, Ryckman KK, Feuer SK, Anderson JG, Franck LS, Gano D, Petersen MA, Oltman SP, Chambers BD, Neuhaus J, Rand L, Jelliffe-Pawlowski LL, Pantell MS

Microglial Gi-dependent dynamics regulate brain network hyperexcitability.

Nature neuroscience

Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K

Newborn metabolic vulnerability profile identifies preterm infants at risk for mortality and morbidity.

Pediatric research

Oltman SP, Rogers EE, Baer RJ, Jasper EA, Anderson JG, Steurer MA, Pantell MS, Petersen MA, Partridge JC, Karasek D, Ross KM, Feuer SK, Franck LS, Rand L, Dagle JM, Ryckman KK, Jelliffe-Pawlowski LL

Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

Nature immunology

Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

Nature immunology

Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K

Neurovascular interactions: Mechanisms, imaging, and therapeutics.

IBRO Reports

Katerina Akassoglou, Reshmi Tognatta, Mark Petersen

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

Nature immunology

Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K

Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.

Brain : a journal of neurology

Lee NJ, Ha SK, Sati P, Absinta M, Luciano NJ, Lefeuvre JA, Schindler MK, Leibovitch EC, Ryu JK, Petersen MA, Silva AC, Jacobson S, Akassoglou K, Reich DS

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.

Nature reviews. Neuroscience

Petersen MA, Ryu JK, Akassoglou K

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Neuron

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Nature communications

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K

Early detection of thrombin activity in neuroinflammatory disease.

Annals of neurology

Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K

220 Fibrinogen/CR3 signaling induces demyelination by promoting Th1 cell differentiation and peripheral macrophage recruitment into the CNS.

Cytokine

Jae Kyu Ryu, Kim M. Baeten, Mark A. Petersen, Sara G. Murray, Anke Meyer-Franke, Dimitrios Davalos, Catherine Bedard, Thomas Prod’homme, Israel F. Charo, Hans Lassmann, Jay L. Degen, Scott S. Zamvil, Katerina Akassoglou

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

Nature communications

Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K